癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Cytochrome P450 2B1 Rabbit pAb
Cytochrome P450 2B1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P00176 |
| Predicted | Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 55934 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from Rat Cytochrome P450 2B1 |
| Epitope Specificity | 301-400/491 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane bound, endoplasmic reticulum |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | phenobarbitol-inducible member of the p450 xenobiotic-inducible superfamily involved in hydroxylation of decanoic and other fatty acids [RGD, Feb 2006] |
| Other Names | Cytochrome P450 2B1, 1.14.14.1, CYPIIB1, Cytochrome P450-B, Cytochrome P450b, Cytochrome P450-LM2, Cytochrome P450-PB1, Cytochrome P450-PB2, Cyp2b1 {ECO:0000303|PubMed:19401463, ECO:0000312|RGD:2466} |
|---|---|
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Cyp2b1 {ECO:0000303|PubMed:19401463, ECO:0000312|RGD:2466} |
|---|---|
| Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
| Cellular Location | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein Mitochondrion inner membrane; Peripheral membrane protein. Note=Post- translationally targeted to mitochondria. Requires the cytosolic chaperones HSP70 and HSP90, for initial targeting to mitochondria, and then requires all three of the receptor proteins in the TOM complex, TOMM70, TOMM20 and TOMM22 for translocation across the mitochondrial outer membrane. After translocation into the matrix, associates with the inner membrane as a membrane extrinsic protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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