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DNAH1 Rabbit pAb
DNAH1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9P2D7 |
| Reactivity | Rat, Human, Mouse |
| Predicted | Pig, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 487498 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DNAH1 |
| Epitope Specificity | 4201-4330/4330 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm > cytoskeleton > cilium axoneme. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH1 (dynein heavy chain 1, axonemal), also known as heat shock regulated protein 1 or ciliary dynein heavy chain 1, is a 4,330 amino acid protein consisting of at least two heavy chains and several intermediate and light chains. Mutations in the gene encoding DNAH1 may be a cause of primary ciliary dyskinesia, also known as Kartagener Syndrome, which is characterized by chronic recurrent respiratory infections due to defective cilia action in the respiratory tract. There are three isoforms of DNAH1 that exist as a result of alternative splicing events. |
| Gene ID | 25981 |
|---|---|
| Other Names | Dynein axonemal heavy chain 1, Axonemal beta dynein heavy chain 1, Ciliary dynein heavy chain 1, Heat shock regulated protein 1, HSRF-1, hDHC7, DNAH1 (HGNC:2940), DHC7, DNAHC1, KIAA1410 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DNAH1 (HGNC:2940) |
|---|---|
| Synonyms | DHC7, DNAHC1, KIAA1410 |
| Function | Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum Note=Recruitment to the sperm flagellum requires interaction with DNAH12. {ECO:0000250|UniProtKB:E9Q8T7} |
| Tissue Location | Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain (PubMed:11175280). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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