癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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C6orf25 Rabbit pAb
C6orf25 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | O95866 |
| Reactivity | Mouse |
| Predicted | Rat, Human, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 26163 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human C6orf25 |
| Epitope Specificity | 1-100/241 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Isoform E: Endoplasmic reticulum. Golgi apparatus.Isoform D: Endoplasmic reticulum. Golgi apparatus.Isoform B: Cell membrane; Single-pass type I membrane protein.Isoform A: Cell membrane; Single-pass type I membrane protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | C6orf25 is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. It is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Gene ID | 80739 |
|---|---|
| Other Names | Megakaryocyte and platelet inhibitory receptor G6b {ECO:0000312|HGNC:HGNC:13937}, Protein G6b, MPIG6B (HGNC:13937) |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MPIG6B (HGNC:13937) |
|---|---|
| Function | Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (PubMed:12665801). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:17311996). Appears to operate in a calcium-independent manner (PubMed:12665801). |
| Cellular Location | [Isoform E]: Endoplasmic reticulum. Golgi apparatus [Isoform B]: Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Expressed in platelets. Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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