癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
C9orf41 Rabbit pAb
C9orf41 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8N4J0 |
| Reactivity | Rat, Mouse |
| Predicted | Pig, Human, Rabbit, Chicken, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 47186 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human C9orf41 |
| Epitope Specificity | 101-200/409 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The C9orf41 gene product has been provisionally designated C9orf41 pending further characterization. |
| Gene ID | 138199 |
|---|---|
| Other Names | Carnosine N-methyltransferase {ECO:0000303|PubMed:26001783, ECO:0000312|HGNC:HGNC:23435}, 2.1.1.22, CARNMT1 (HGNC:23435) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CARNMT1 (HGNC:23435) |
|---|---|
| Function | Protein-histidine N-methyltransferase that specifically catalyzes the N1-methylation (pros-methylation) of histidine residues in a wide range of proteins. It primarily monomethylates proteins containing RNA-binding C3H1 zinc finger motifs, such as U2AF1, ZC3H15, ZC3H18, PPP1R10, PRR3 and RNF113A, thereby modulating mRNA splicing and turnover (PubMed:37612136, PubMed:39198440, PubMed:40473212). Additionally, methylates the dipeptide carnosine (beta-alanyl-L- histidine) at the N1 position to generate anserine, an abundant component of vertebrate skeletal muscle. Acts also on other L- histidine-containing di- and tripeptides, such as Gly-Gly-His, Gly-His, and homocarnosine (GABA-His) (PubMed:26001783). |
| Cellular Location | Cytoplasm, cytosol. Nucleus |
| Tissue Location | Expressed at higher level in kidney. Expressed at lower level in brain and skeletal muscle |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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