癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IER2 Rabbit pAb
IER2 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9BTL4 |
| Predicted | Rat, Dog, Human, Mouse, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24196 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human IER2 |
| Epitope Specificity | 1-100/223 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | IER2 is a 223 amino acid protein belonging to the immediate early response (IER) family. IER proteins are the first gene products to be induced during growth stimulation and/or arrest. IER2 expression can be induced by growth factors,12-O-tetradecanoylphorbol-13-acetate (TPA) or Okadaic acid. The coding region of IER2 contains regions of similarity to the transcription factor proteins that are encoded by the Jun oncogene family, possibly indicating a role for IER2 in transcription regulation. Further evidence for this role includes a GUUUG sequence in the 3’ flanking region of IER2, which is believed to be a mRNA degradation signal similar to those found in transcription regulators. |
| Gene ID | 9592 |
|---|---|
| Other Names | Immediate early response gene 2 protein, Protein ETR101, IER2 (HGNC:28871) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IER2 (HGNC:28871) |
|---|---|
| Function | DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713). |
| Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation |
| Tissue Location | Expressed in activated T-cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
