癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
IFFO Rabbit pAb
IFFO Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q0D2I5 |
| Reactivity | Mouse |
| Predicted | Rat, Dog, Human, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61979 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human IFFO |
| Epitope Specificity | 401-500/559 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Intermediate filaments are composed of two-chain, a-helical, coiled-coil molecules arranged on an imperfect helical lattice. They have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is a general marker of cells originating in the mesenchyme and is frequently co-expressed with other members of the intermediate filament family, such as the cytokeratins, in certain neoplasms. Vimentin and Desmin, a related class III intermediate filament, are both expressed during skeletal muscle development. Desmuslin links Desmin to the extracellular matrix and provides structural support in muscle. HOM-TES-103, also known as intermediate filament family orphan 1 (IFFO1), is a 559 amino acid protein that belongs to the intermediate filament family. Ubiquitously expressed, HOM-TES-103 exists as seven alternatively spliced isoforms. |
| Gene ID | 25900 |
|---|---|
| Other Names | Non-homologous end joining factor IFFO1, NHEJ factor IFFO1, Intermediate filament family orphan 1, Tumor antigen HOM-TES-103, IFFO1 (HGNC:24970), IFFO |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | IFFO1 (HGNC:24970) |
|---|---|
| Synonyms | IFFO |
| Function | Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). |
| Cellular Location | Nucleus. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus matrix. Note=Mainly soluble, the remaining is localized in the nuclear matrix (PubMed:31548606). Localized at double- strand break (DSB) sites near the lamina and nuclear matrix structures (PubMed:31548606). |
| Tissue Location | Ubiquitously expressed. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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