癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FBLL1 Rabbit pAb
FBLL1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | A6NHQ2 |
| Predicted | Rat, Pig, Dog, Human, Mouse, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34803 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FBLL1 |
| Epitope Specificity | 101-200/333 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nuclear, nucleolus. Note=Fibrillar region of the nucleolus (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. |
| Gene ID | 345630 |
|---|---|
| Other Names | RNA 2'-O-methyltransferase FBLL1, 2.1.1.-, Fibrillarin like 1 {ECO:0000312|HGNC:HGNC:35458}, FBLL1 (HGNC:35458) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FBLL1 (HGNC:35458) |
|---|---|
| Function | S-adenosyl-L-methionine-dependent RNA methyltransferase that catalyzes 2'-hydroxyl ribose methylation in RNAs (PubMed:39570315). Functions as part of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes, where guide snoRNAs ensure methylation specificity through base pairing with RNA substrates (PubMed:39570315). Exhibits broad substrate specificity, methylating multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) depending on the guide snoRNA incorporated in the complex (PubMed:39570315). Specifically expressed in brain, it regulates the expression of GAP43 by stabilizing its mRNA through methylation and thereby plays an indirect role in neuronal differentiation (By similarity). |
| Cellular Location | Nucleus, nucleolus. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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