癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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FOXJ3 Rabbit pAb
FOXJ3 Rabbit pAb
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Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9UPW0 |
| Reactivity | Mouse |
| Predicted | Human, Rat, Dog, Horse, Rabbit, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 68960 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FOXJ3 |
| Epitope Specificity | 121-220/622 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Contains 1 fork-head DNA-binding domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | FOXJ3 (forkhead box protein J3) is a 622 amino acid protein encoded by the human gene FOXJ3. FOXJ3, having one forkhead DNA-binding domain, is a novel forkhead factor and, as such, belongs to the forkhead protein family. The HNF3/forkhead family includes a large number of transcription factors that share a structurally related DNA binding domain. Forkhead factors are known to play important roles both during development and in adults. FOXJ3 is expressed in neuroectoderm, in neural crest, and in many structures derived from neural crest cells, such as facioacoustic, trigeminal and dorsal root ganglia. Stripes of FOXJ3 expression appear in the location of myotomes and expand ventrally in a pattern similar to the developing body wall musculature. Developing limbs have a complex pattern of FOXJ3 expression that at E12.5 colocalizes with the condensed mesenchyme of the skeletal primordia. |
| Gene ID | 22887 |
|---|---|
| Other Names | Forkhead box protein J3, FOXJ3, KIAA1041 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | FOXJ3 |
|---|---|
| Synonyms | KIAA1041 |
| Function | Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
FOXJ3 (forkhead box protein J3) is a 622 amino acid protein encoded by the human gene FOXJ3. FOXJ3, having one forkhead DNA-binding domain, is a novel forkhead factor and, as such, belongs to the forkhead protein family. The HNF3/forkhead family includes a large number of transcription factors that share a structurally related DNA binding domain. Forkhead factors are known to play important roles both during development and in adults. FOXJ3 is expressed in neuroectoderm, in neural crest, and in many structures derived from neural crest cells, such as facioacoustic, trigeminal and dorsal root ganglia. Stripes of FOXJ3 expression appear in the location of myotomes and expand ventrally in a pattern similar to the developing body wall musculature. Developing limbs have a complex pattern of FOXJ3 expression that at E12.5 colocalizes with the condensed mesenchyme of the skeletal primordia.
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