癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GALNTL1 Rabbit pAb
GALNTL1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8N428 |
| Reactivity | Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 63074 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human GALNTL1 |
| Epitope Specificity | 51-150/558 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Golgi apparatus membrane; Single pass type II membrane protein |
| SIMILARITY | Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.Contains 1 ricin B-type lectin domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosaminyl) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-TL1 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1), also known as GALNT16, is a 588 amino acid single-pass type II membrane protein belonging to the glycosyltransferase 2 family, which localizes to the Golgi apparatus. GalNAc-TL1 utilizes manganese and calcium as cofactors, and catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, which involves the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Containing one ricin B-type lectin domain, GalNAc-TL1 exists as two alternatively spliced isoforms. |
| Gene ID | 57452 |
|---|---|
| Other Names | Polypeptide N-acetylgalactosaminyltransferase 16, 2.4.1.41, Polypeptide GalNAc transferase 16, GalNAc-T16, Polypeptide GalNAc transferase-like protein 1, GalNAc-T-like protein 1, pp-GaNTase-like protein 1, Polypeptide N-acetylgalactosaminyltransferase-like protein 1, Protein-UDP acetylgalactosaminyltransferase-like protein 1, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 1, GALNT16, GALNTL1, KIAA1130 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | GALNT16 |
|---|---|
| Synonyms | GALNTL1, KIAA1130 |
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosaminyl) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-TL1 (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1), also known as GALNT16, is a 588 amino acid single-pass type II membrane protein belonging to the glycosyltransferase 2 family, which localizes to the Golgi apparatus. GalNAc-TL1 utilizes manganese and calcium as cofactors, and catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, which involves the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Containing one ricin B-type lectin domain, GalNAc-TL1 exists as two alternatively spliced isoforms.
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