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KLHL15 Rabbit pAb
KLHL15 Rabbit pAb
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q96M94 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Pig, Horse, Rabbit, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 69775 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KLHL15 |
| Epitope Specificity | 401-500/604 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 5 Kelch repeats. |
| SUBUNIT | Interacts with CUL3. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | KLHL15 is believed to be a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which regulates the ubiquitination, and subsequent proteasomal degradation, of target proteins. KLHL15 contains one BACK (BTB/Kelch associated) domain, five kelch repeats and one BTB domain. The BTB (broad complex, tramtrack and bric-a-brac) domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. |
| Gene ID | 80311 |
|---|---|
| Other Names | Kelch-like protein 15, KLHL15, KIAA1677 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | KLHL15 |
|---|---|
| Synonyms | KIAA1677 |
| Function | Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex (PubMed:14528312, PubMed:27561354, PubMed:35219381). Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits (PubMed:23135275). Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation (PubMed:27561354, PubMed:35219381). Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:27561354, PubMed:35219381). |
| Cellular Location | Nucleus. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
KLHL15 is believed to be a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which regulates the ubiquitination, and subsequent proteasomal degradation, of target proteins. KLHL15 contains one BACK (BTB/Kelch associated) domain, five kelch repeats and one BTB domain. The BTB (broad complex, tramtrack and bric-a-brac) domain, also known as the POZ (poxvirus and zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function.
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