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KCNS1 Rabbit pAb
KCNS1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q96KK3 |
| Reactivity | Rat |
| Predicted | Dog, Human, Mouse, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58372 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KCNS1 |
| Epitope Specificity | 161-260/526 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane. May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008] |
| Gene ID | 3787 |
|---|---|
| Other Names | Delayed-rectifier potassium channel regulatory subunit KCNS1, Delayed-rectifier K(+) channel alpha subunit 1, Delayed-rectifier potassium channel subunit Kv9.1, hKv9.1, Potassium voltage-gated channel modifier subfamily S member 1 {ECO:0000312|HGNC:HGNC:6300}, KCNS1 (HGNC:6300) |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KCNS1 (HGNC:6300) |
|---|---|
| Function | Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values (PubMed:10484328). While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2 (PubMed:10484328). Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:10484328) |
| Tissue Location | Detected in all tissues tested with the exception of skeletal muscle (PubMed:10484328). Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis (PubMed:10484328). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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