癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KCTD6 Rabbit pAb
KCTD6 Rabbit pAb
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- 背景知识
Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8NC69 |
| Reactivity | Rat, Pig, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 27610 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KCTD6 |
| Epitope Specificity | 101-200/237 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Contains 1 BTB (POZ) domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | KCTD6 (potassium channel tetramerisation domain containing 6) is a 237 amino acid protein that contains one BTB domain, suggesting a possible role as a transcriptional regulator. The gene encoding KCTD6 maps to chromosome 3, which contains over 1,100 genes. Notably, a chemokine receptor gene cluster and a variety of human cancer related loci reside on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells as well. |
| Gene ID | 200845 |
|---|---|
| Other Names | BTB/POZ domain-containing protein KCTD6, KCASH3 protein, Potassium channel tetramerization domain-containing protein 6, KCTD6 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | KCTD6 |
|---|---|
| Function | Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887). |
| Cellular Location | Cytoplasm, myofibril, sarcomere, M line. Note=Colocalizes with ANK1 isoform Mu17 at the M line in differentiated skeletal muscle cells and heart |
| Tissue Location | Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
KCTD6 (potassium channel tetramerisation domain containing 6) is a 237 amino acid protein that contains one BTB domain, suggesting a possible role as a transcriptional regulator. The gene encoding KCTD6 maps to chromosome 3, which contains over 1,100 genes. Notably, a chemokine receptor gene cluster and a variety of human cancer related loci reside on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells as well.
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