癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KIAA1161 Rabbit pAb
KIAA1161 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q6NSJ0 |
| Reactivity | Rat |
| Predicted | Dog, Human, Mouse, Rabbit, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 81087 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KIAA1161 |
| Epitope Specificity | 631-714/714 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | KIAA1161 is a 714 amino acid protein that belongs to the glycosyl hydrolase 31 family and functions as a putative glucosidase. This single-pass type II membrane protein is post-translationally phosphorylated at serine 44 and glycosylated at amino acid positions 240 and 250. The gene encoding KIAA1161 maps to human chromosome 9, which consists of about 145 million bases, comprises approximately 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. |
| Gene ID | 57462 |
|---|---|
| Other Names | Alpha-galactosidase MYORG, 3.2.1.22, Myogenesis regulating glycosidase {ECO:0000312|HGNC:HGNC:19918}, Nuclear envelope transmembrane protein 37, MYORG (HGNC:19918) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MYORG (HGNC:19918) |
|---|---|
| Function | Alpha-galactosidase with unusual specificity for the Gal- alpha1,4-Glc structure, whose in vivo substrate is still unknown (PubMed:36129849). Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2 (By similarity). |
| Cellular Location | Nucleus membrane {ECO:0000250|UniProtKB:Q69ZQ1}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q69ZQ1} Endoplasmic reticulum membrane; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q69ZQ1}. Note=Only a minor fraction is present in the peripheral endoplasmic reticulum {ECO:0000250|UniProtKB:Q69ZQ1} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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