癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SLC4A7 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 文献引用 : 3
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y6M7 |
| Other Accession | NP_003606.3 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Bovine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 136044 Da |
| Antigen Region | 1186-1214 aa |
| Gene ID | 9497 |
|---|---|
| Other Names | Sodium bicarbonate cotransporter 3, Electroneutral Na/HCO(3) cotransporter, Sodium bicarbonate cotransporter 2, Sodium bicarbonate cotransporter 2b, Bicarbonate transporter, Solute carrier family 4 member 7, SLC4A7, BT, NBC2, NBC2B, NBC3, NBCn1, SBC2, SLC4A6 |
| Target/Specificity | This SLC4A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1186-1214 amino acids from the C-terminal region of human SLC4A7. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC4A7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SLC4A7 |
|---|---|
| Synonyms | BT, NBC2, NBC2B, NBC3, NBCn1, SBC2, SLC4 |
| Function | Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14578046, PubMed:14736710). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (PubMed:35772404). |
| Cellular Location | Basolateral cell membrane {ECO:0000250|UniProtKB:Q9R1N3}; Multi-pass membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:Q9R1N3}; Multi-pass membrane protein. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q9R1N3}. Cell membrane; Multi-pass membrane protein. Note=Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity). {ECO:0000250|UniProtKB:Q9R1N3} |
| Tissue Location | Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SLC4A7 regulates intracellular pH and may also play a role in bicarbonate salvage in secretory epithelia. Additionally, SLC4A7 may also have associated sodium channel activity.
REFERENCES
Odefrey, F., et al. Cancer Res. 70(4):1449-1458(2010)
Ahmed, S., et al. Nat. Genet. 41(5):585-590(2009)
Ishiguro, H., et al. Addiction 102(8):1320-1325(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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