癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TPGS1 Rabbit pAb
TPGS1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q6ZTW0 |
| Predicted | Rat, Dog, Human, Mouse, Rabbit, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 31275 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TPGS1 |
| Epitope Specificity | 21-120/290 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Microtubule. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | TPCN1 is a widely expressed, 816 amino acid voltage-gated cation channel protein with predominant expression in lung, liver, heart and kidney. In the kidney, TPCN1 localizes to the inner medullary collecting ducts. In contrast with the distantly related four-domain voltage-gated calcium and sodium channels and the more closely related four-domain ion transport protein located on the surface of sperm cells (CatSper), TPCN1 is a two-domain channel. Similar to the four-domain channel structure, each of the two homologous domains that comprise TPCN1 contains six transmembrane segments (S1-S6) with a pore loop between S5 and S6 and a voltage sensor segment that is positively charged. TPCN1 has hydrophilic N- and C-termini that localize to the cytoplasm. |
| Gene ID | 91978 |
|---|---|
| Other Names | Tubulin polyglutamylase complex subunit 1, PGs1, TPGS1 (HGNC:25058), C19orf20 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TPGS1 (HGNC:25058) |
|---|---|
| Synonyms | C19orf20 |
| Function | Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility (Probable). May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q99MS8}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q99MS8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q99MS8}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:Q99MS8}. Cell projection, axon {ECO:0000250|UniProtKB:Q99MS8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99MS8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q99MS8} Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes. {ECO:0000250|UniProtKB:Q99MS8} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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