癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SCAPER Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q9BY12 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 158287 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SCAPER |
| Epitope Specificity | 31-130/140 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Endoplasmic reticulum. Nucleus. Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus. |
| SIMILARITY | Contains 1 C2H2-type zinc finger. |
| Post-translational modifications | Phosphorylated in vitro by the CCNA2/CDK2 complex. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SCAPER is a 1,399 amino acid protein that contains a C2H2-type zinc finger, a putative transmembrane domain, an ER retrieval signal at the C terminus, four coiled-coil domains, six potential RXL motifs that might confer binding to cyclins and six consensus Cdk phosphorylation sites. SCAPER interacts with, and is phosphorylated in vitro by, the cyclin A/Cdk2 complex at multiple phases of the cell cycle, including S and G2/M. It has been suggested that SCAPER represents a novel cyclin A/Cdk2 regulatory protein that transiently maintains cyclin A in the cytoplasm. The SCAPER protein is predominantly located in the endoplasmic reticulum, with only a small portion detected in the nucleus. Widely expressed, SCAPER demonstrates highest expression in testis. Existing as two alternatively spliced isoforms, the SCAPER gene is conserved in chimpanzee, dog, mouse, rat, chicken and zebrafish, and maps to human chromosome 15q24.3. |
| Gene ID | 49855 |
|---|---|
| Other Names | S phase cyclin A-associated protein in the endoplasmic reticulum, S phase cyclin A-associated protein in the ER, Zinc finger protein 291, SCAPER, KIAA1454, ZNF291 |
| Target/Specificity | Widely expressed with highest expression in testis. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | SCAPER (HGNC:13081) |
|---|---|
| Synonyms | KIAA1454, ZNF291 |
| Function | CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm. |
| Cellular Location | Endoplasmic reticulum. Nucleus Note=Predominantly located in the endoplasmic reticulum, only a small portion is detected in the nucleus |
| Tissue Location | Widely expressed with high expression in testis. Isoform 1 is detected in various tissues, including retina, fetal and adult brain. Isoform 2 is expressed in the retina at high levels, and in the brain at very low levels (PubMed:28794130) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
