癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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HCFC1R1 Rabbit pAb
HCFC1R1 Rabbit pAb
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- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9NWW0 |
| Reactivity | Mouse, Rat |
| Predicted | Human, Chicken, Dog, Pig, Horse, Rabbit, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 15291 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HCFC1R1 |
| Epitope Specificity | 1-100/138 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | PSTPIP1 is a 416 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one SH3 domain and one FCH domain. Expressed at high levels in T cells and spleen and present at lower levels in thymus, lung, placenta and small intestine, PSTPIP1 interacts with CD2AP, BDP1 and c-Abl and is involved in the regulation of the Actin cytoskeleton, possibly functioning as a scaffold protein that may promote Actin polymerization. Defects in the gene encoding PSTPIP1 are the cause of PAPA syndrome (PAPAS), an autosomal dominant disease characterized by recurring inflammatory episodes that affect skin and joint tissue. Multiple isoforms of PSTPIP1 exist due to alternative splicing events. |
| Gene ID | 54985 |
|---|---|
| Other Names | Host cell factor C1 regulator 1, HCF-1 beta-propeller-interacting protein, HCFC1R1, HPIP |
| Target/Specificity | Widely expressed. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | HCFC1R1 |
|---|---|
| Synonyms | HPIP |
| Function | Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. |
| Cellular Location | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner |
| Tissue Location | Widely expressed.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
PSTPIP1 is a 416 amino acid protein that localizes to both the cytoplasm and the cytoskeleton and contains one SH3 domain and one FCH domain. Expressed at high levels in T cells and spleen and present at lower levels in thymus, lung, placenta and small intestine, PSTPIP1 interacts with CD2AP, BDP1 and c-Abl and is involved in the regulation of the Actin cytoskeleton, possibly functioning as a scaffold protein that may promote Actin polymerization. Defects in the gene encoding PSTPIP1 are the cause of PAPA syndrome (PAPAS), an autosomal dominant disease characterized by recurring inflammatory episodes that affect skin and joint tissue. Multiple isoforms of PSTPIP1 exist due to alternative splicing events.
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