癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OSAP/Ovary-specific acidic protein Rabbit pAb
OSAP/Ovary-specific acidic protein Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q8TDB4 |
| Reactivity | Mouse |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25390 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human OSAP/Ovary-specific acidic protein |
| Epitope Specificity | 1-100/240 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Gene ID | 84709 |
|---|---|
| Other Names | Protein MGARP, Corneal endothelium-specific protein 1, CESP-1, Hypoxia up-regulated mitochondrial movement regulator protein, Mitochondria-localized glutamic acid-rich protein, Ovary-specific acidic protein, MGARP, C4orf49, CESP1, HUMMR, OSAP |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MGARP |
|---|---|
| Synonyms | C4orf49, CESP1, HUMMR, OSAP |
| Function | Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). Plays an inhibitory role during neocortex development by regulating mitochondrial morphology, distribution and motility in neocortical neurons (By similarity). |
| Cellular Location | Mitochondrion. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8VI64}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8VI64}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q8VI64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8VI64}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion. {ECO:0000250|UniProtKB:Q8VI64} |
| Tissue Location | Expressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid-producing cells of the ovary and testis. Weakly expressed in placenta. Expressed in corneal endothelial cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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