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SPESP1 Rabbit pAb
SPESP1 Rabbit pAb
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- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q6UW49 |
| Reactivity | Human |
| Predicted | Rat, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38931 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SPESP1 |
| Epitope Specificity | 151-250/350 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasmic vesicle > secretory vesicle > acrosome. Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome. |
| SIMILARITY | Belongs to the SPESP1 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SPESP1 is a 399 amino acid protein belonging to the SPESP1 family. Localizing to cytoplasmic vesicle, secretory vesicle, and acrosome, SPESP1 is highly expressed in testis, with lower levels found in placenta and fetal lung. SPESP1 establishes an equatorial segment subcompartment early in sperm development and is required for proper sperm-egg fusion. Disruption of SPESP1 leads to abnormal distribution of sperm proteins resulting in a detached membrane from the equatorial segment and less fertile sperm. SPESP1 may interact with IZUMO1 and MN9 antigen and contains an N-glycosylation site as well as several cAMP-dependent kinase, protein kinase C, and casein kinase II consensus phosphorylation sites. |
| Gene ID | 246777 |
|---|---|
| Other Names | Sperm equatorial segment protein 1 {ECO:0000312|HGNC:HGNC:15570}, SP-ESP, Equatorial segment protein, ESP, Glycosylated 38 kDa sperm protein C-7/8, SPESP1 (HGNC:15570) |
| Target/Specificity | Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages of spermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed in placenta and fetal lung. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | SPESP1 (HGNC:15570) |
|---|---|
| Function | Involved in fertilization ability of sperm. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (PubMed:12773409). After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity) {ECO:0000250|UniProtKB:Q9D5A0, ECO:0000269|PubMed:12773409} |
| Tissue Location | Highly expressed in testis, where it is localized in the acrosome of postmeiotic stages of spermiogenesis (round and elongating spermatids and in ejaculated spermatozoa) (at protein level). Poorly expressed in placenta and fetal lung |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
SPESP1 is a 399 amino acid protein belonging to the SPESP1 family. Localizing to cytoplasmic vesicle, secretory vesicle, and acrosome, SPESP1 is highly expressed in testis, with lower levels found in placenta and fetal lung. SPESP1 establishes an equatorial segment subcompartment early in sperm development and is required for proper sperm-egg fusion. Disruption of SPESP1 leads to abnormal distribution of sperm proteins resulting in a detached membrane from the equatorial segment and less fertile sperm. SPESP1 may interact with IZUMO1 and MN9 antigen and contains an N-glycosylation site as well as several cAMP-dependent kinase, protein kinase C, and casein kinase II consensus phosphorylation sites.
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