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SPG11 Rabbit pAb
SPG11 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q96JI7 |
| Reactivity | Human, Mouse |
| Predicted | Dog, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 278868 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SPG11 |
| Epitope Specificity | 2151-2250/2443 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane. Cytoplasm > cytosol. Nucleus. Mainly cytoplasmic. |
| SUBUNIT | Interacts with AP5Z1, AP5B1, AP5S1 and ZFYVE26. |
| Post-translational modifications | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| DISEASE | Defects in SPG11 are the cause of spastic paraplegia autosomal recessive type 11 (SPG11) [MIM:604360]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| Gene ID | 80208 |
|---|---|
| Other Names | Spatacsin, Colorectal carcinoma-associated protein, Spastic paraplegia 11 protein, SPG11, KIAA1840 |
| Target/Specificity | Expressed in all structures of brain, with a high expression in cerebellum. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | SPG11 |
|---|---|
| Synonyms | KIAA1840 |
| Function | May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. |
| Cellular Location | Cytoplasm, cytosol. Nucleus. Cell projection, axon. Cell projection, dendrite. Note=Mainly cytoplasmic |
| Tissue Location | Expressed in all structures of brain, with a high expression in cerebellum. Expressed in cortical projection neurons |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
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