癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SPOCD1 Rabbit pAb
SPOCD1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q6ZMY3 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 130027 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SPOCD1 |
| Epitope Specificity | 361-450/1216 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SPOCD1 is a 1,216 amino acid protein that contains one SPOC domain and one TFIIS central domain. SPOCD1 exists as five alternatively spliced isoforms, with isoform 1 showing expression in lung. The gene that encodes SPOCD1 contains 25,630 bases and maps to human chromosome 1p35.2. Spanning about 260 million base pairs and making up 8% of the human genome, chromosome 1 is the largest human chromosome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1 and aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. |
| Gene ID | 90853 |
|---|---|
| Other Names | SPOC domain-containing protein 1, SPOCD1 {ECO:0000303|PubMed:38359823, ECO:0000312|HGNC:HGNC:26338} |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SPOCD1 {ECO:0000303|PubMed:38359823, ECO:0000312|HGNC:HGNC:26338} |
|---|---|
| Function | Protein adapter that acts as an essential executor of PIWIL4- piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (PubMed:38359823). Recruited to young transposons, which are specifically marked with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3), via its association with SPIN1 chromatin reader, and associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (By similarity). Following this, PIWIL4 engages with nascent transposable element transcript to direct piRNA-directed DNA methylation. Not required for piRNA biosynthesis (By similarity). |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:B1ASB6}. Chromosome {ECO:0000250|UniProtKB:B1ASB6} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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