癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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MORN4/C10orf83 Rabbit pAb
MORN4/C10orf83 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8NDC4 |
| Reactivity | Mouse |
| Predicted | Rat, Dog, Human, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 16236 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MORN4/C10orf83 |
| Epitope Specificity | 101-146/146 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | MORN4 is a 146 amino acid protein that contains four MORN repeats and exists as two alternatively spliced isoforms. The gene encoding MORN4 maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10. As with most trisomies, trisomy 10 is rare and is deleterious. |
| Gene ID | 118812 |
|---|---|
| Other Names | MORN repeat-containing protein 4, Protein 44050, Retinophilin, MORN4, C10orf83 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MORN4 |
|---|---|
| Synonyms | C10orf83 |
| Function | Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. |
| Cellular Location | Cytoplasm. Cell projection, filopodium tip. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q6PGF2}. Note=Found in the cytoplasm in the absence of MYO3A and localizes at filopodial tips in the presence of MYO3A. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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