癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MSL1v1/CENP36 Rabbit pAb
MSL1v1/CENP36 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q7Z3B3 |
| Reactivity | Rat |
| Predicted | Pig, Dog, Human, Mouse, Rabbit, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 120966 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MSL1v1/CENP36 |
| Epitope Specificity | 501-600/1105 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Expressed in the brain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012] |
| Gene ID | 284058 |
|---|---|
| Other Names | KAT8 regulatory NSL complex subunit 1, MLL1/MLL complex subunit KANSL1, MSL1 homolog 1, hMSL1v1, NSL complex protein NSL1, Non-specific lethal 1 homolog, KANSL1, CENP-36, KIAA1267, MSL1V1, NSL1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KANSL1 |
|---|---|
| Synonyms | CENP-36, KIAA1267, MSL1V1, NSL1 |
| Function | Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146). |
| Cellular Location | Nucleus. Chromosome, centromere, kinetochore. Mitochondrion. Cytoplasm, cytoskeleton, spindle pole. Note=Concentrated in the nucleus during interphase, localizes to the spindle poles and pericentriolar region during prometaphase and metaphase, and remains associated with the spindle poles throughout anaphase. |
| Tissue Location | Expressed in the brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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