癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
C12orf72 Rabbit pAb
C12orf72 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q8IXQ9 |
| Reactivity | Rat |
| Predicted | Dog, Human, Mouse, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 29461 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human C12orf72 |
| Epitope Specificity | 61-160/262 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. ARHGAP36 (Rho GTPase activating protein 36) is a 547 amino acid protein that contains one Rho-GAP domain. Conserved in chimpanzee, dog, cow, mouse and rat, ARHGAP36 exists as five alternatively spliced isoforms and is encoded by a gene that maps to human chromosome Xq26.1. Chromosome X consists of nearly 153 million base pairs encoding approximately 1,000 genes. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are X chromosome-linked conditions that affect males more frequently because males carry a single X chromosome. |
| Gene ID | 254013 |
|---|---|
| Other Names | Electron transfer flavoprotein beta subunit lysine methyltransferase, 2.1.1.-, ETFB lysine methyltransferase, ETFB-KMT, Protein N-lysine methyltransferase METTL20, ETFBKMT (HGNC:28739), C12orf72, METTL20 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ETFBKMT (HGNC:28739) |
|---|---|
| Synonyms | C12orf72, METTL20 |
| Function | Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781). |
| Cellular Location | Cytoplasm. Mitochondrion matrix. Note=Concentrated in cytoplasmic granular foci. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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