癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ZNF136 Rabbit pAb
ZNF136 Rabbit pAb
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- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P52737 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 62784 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZNF136 |
| Epitope Specificity | 451-540/540 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 14 C2H2-type zinc fingers. Contains 1 KRAB domain. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ZNF136 is a transcriptional regulator belonging to the Krüppel C2H2-type zinc-finger protein family. It is a ubiquitously expressed protein, localizes to the nucleus and contains 14 C2H2-type zinc fingers and 1 KRAB A-domain. Alone, ZNF136 functions as a weak repressor; however, when fused with a heterologous KRAB B-domain containing protein, such as ZNF10, ZNF136 functions as a potent repressor. |
| Gene ID | 7695 |
|---|---|
| Other Names | Zinc finger protein 136, ZNF136 |
| Target/Specificity | Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | ZNF136 |
|---|---|
| Function | May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain. |
| Cellular Location | Nucleus. |
| Tissue Location | Seems ubiquitous. Seen in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ZNF136 is a transcriptional regulator belonging to the Krüppel C2H2-type zinc-finger protein family. It is a ubiquitously expressed protein, localizes to the nucleus and contains 14 C2H2-type zinc fingers and 1 KRAB A-domain. Alone, ZNF136 functions as a weak repressor; however, when fused with a heterologous KRAB B-domain containing protein, such as ZNF10, ZNF136 functions as a potent repressor.
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