癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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ARFGAP2 Rabbit pAb
ARFGAP2 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q8N6H7 |
| Reactivity | Rat, Pig, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 56720 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ZNF289/ARFGAP2 |
| Epitope Specificity | 401-500/521 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note: Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. |
| SIMILARITY | Contains 1 Arf-GAP domain. |
| SUBUNIT | Interacts with the coatomer complex. Interacts with the C-terminal appendage domain of COPG1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | ZNF289 functions as a GTPase-activating protein (GAP) for ARF family proteins. Localizing to the cytoplasmic side of the Golgi apparatus, ZNF289 contains one ARF-GAP domain and is found associated with COP-I-coated vesicles. |
| Gene ID | 84364 |
|---|---|
| Other Names | ADP-ribosylation factor GTPase-activating protein 2, ARF GAP 2, GTPase-activating protein ZNF289, Zinc finger protein 289, ARFGAP2, ZNF289 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | ARFGAP2 |
|---|---|
| Synonyms | ZNF289 |
| Function | GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. |
| Cellular Location | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ZNF289 functions as a GTPase-activating protein (GAP) for ARF family proteins. Localizing to the cytoplasmic side of the Golgi apparatus, ZNF289 contains one ARF-GAP domain and is found associated with COP-I-coated vesicles.
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