LYPD6 Rabbit pAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P, IHC-F, IF, E
Primary Accession	Q86Y78
Predicted	Rat, Pig, Human, Mouse, Rabbit, Dog, Sheep
Host	Rabbit
Clonality	Polyclonal
Calculated MW	19118 Da
Physical State	Liquid
Immunogen	KLH conjugated synthetic peptide derived from human LYPD6
Epitope Specificity	61-160/171
Isotype	IgG
Purity	affinity purified by Protein A
Buffer	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SUBCELLULAR LOCATION	Secreted
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Background Descriptions	Members of the LY6 protein family (see SLURP1; MIM 606119), such as LYPD6, have at least one 80-amino acid LU domain that contains 10 conserved cysteines with a defined disulfide-bonding pattern (Zhang et al., 2010 [PubMed 19653121]).[supplied by OMIM, Apr 2010]

Additional Information
Gene ID	130574
Other Names	Ly6/PLAUR domain-containing protein 6, LYPD6
Dilution	IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	LYPD6
Function	Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:27344019, PubMed:34631692). Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (PubMed:34631692). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).
Cellular Location	Secreted. Cytoplasm. Cell membrane; Lipid-anchor, GPI-anchor Synapse, synaptosome {ECO:0000250\|UniProtKB:D3ZTT2}. Membrane raft {ECO:0000250\|UniProtKB:Q66IA6}. Cell projection, dendrite {ECO:0000250\|UniProtKB:D3ZTT2}. Perikaryon {ECO:0000250\|UniProtKB:D3ZTT2}. Note=Colocalizes with alpha-3:beta- 4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus. {ECO:0000250\|UniProtKB:D3ZTT2}
Tissue Location	Detected in the temporal cortex (at protein level) (PubMed:25680266). Ubiquitous (PubMed:19653121). Highly expressed in brain and heart (PubMed:19653121).