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MEGF11 Rabbit pAb
MEGF11 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | A6BM72 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Dog, Human, Rabbit, Zebrafish, Chicken, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 110844 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MEGF11 |
| Epitope Specificity | 801-900/1044 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Note: Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | MEGF11 is a 1,044 amino acid single-pass type I membrane protein that belongs to the MEGF family. MEGF11 exists as a homopolymer that primarily localizes to protruding lamellipodia in an irregular, mosaic-like adhesion pattern. Expressed at high levels in adult and fetal brain and adult spinal cord, MEGF11 is found at lower levels in kidney, ovary and heart. MEGF11 contains fourteen EGF-like domains, one EMI domain, and undergoes alternative splicing events to produce four isoforms. The gene encoding MEGF11 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes. |
| Gene ID | 84465 |
|---|---|
| Other Names | Multiple epidermal growth factor-like domains protein 11, Multiple EGF-like domains protein 11, MEGF11, KIAA1781 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MEGF11 |
|---|---|
| Synonyms | KIAA1781 |
| Function | May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein Basolateral cell membrane; Single-pass type I membrane protein. Note=Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to protruding lamellipodia. Does not localize with MEGF10 |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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