癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RPUSD3 Rabbit pAb
RPUSD3 Rabbit pAb
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Application 
| WB |
|---|---|
| Primary Accession | Q6P087 |
| Reactivity | Mouse |
| Predicted | Pig, Dog, Human, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38461 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human RPUSD3 |
| Epitope Specificity | 31-130/351 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nuclear |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | RPUSD3 belongs to the pseudouridine synthase rluA family. Members of this family are involved in modifying bases in RNA molecules. Pseudouridine synthases are responsible for synthesis of pseudouridine from uracil. |
| Gene ID | 285367 |
|---|---|
| Other Names | Mitochondrial mRNA pseudouridine synthase RPUSD3, 5.4.99.-, RNA pseudouridylate synthase domain-containing protein 3, RPUSD3 {ECO:0000303|PubMed:27667664, ECO:0000312|HGNC:HGNC:28437} |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RPUSD3 {ECO:0000303|PubMed:27667664, ECO:0000312|HGNC:HGNC:28437} |
|---|---|
| Function | Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post- transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis (PubMed:27667664). |
| Cellular Location | Mitochondrion matrix. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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