癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DHB13 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| WB, IHC-P-Leica, E |
|---|---|
| Primary Accession | Q7Z5P4 |
| Other Accession | NP_835236.2 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Bovine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 33655 Da |
| Antigen Region | 81-110 aa |
| Gene ID | 345275 |
|---|---|
| Other Names | 17-beta-hydroxysteroid dehydrogenase 13, 17-beta-HSD 13, 11--, Short-chain dehydrogenase/reductase 9, HSD17B13, SCDR9 |
| Target/Specificity | This DHB13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human DHB13. |
| Dilution | WB~~1:1000 IHC-P-Leica~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DHB13 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | HSD17B13 (HGNC:18685) |
|---|---|
| Function | Plays a pivotal role in hepatic lipid metabolism (PubMed:29562163). In vitro, it catalyzes the oxidation of a variety of lipid substrates, including 17beta-estradiol, retinol, retinal, and leukotriene B4 (PubMed:29562163, PubMed:30415504, PubMed:32973038). |
| Cellular Location | [Isoform 2]: Lipid droplet. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VCR2}. Note=Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation. {ECO:0000250|UniProtKB:Q8VCR2} |
| Tissue Location | Highly expressed in the liver (PubMed:29562163). Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :
Liu, S., et al. Acta Biochim. Pol. 54(1):213-218(2007)
Yamada, S., et al. Oncogene 23(35):5901-5911(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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Cat# AP5729A
