癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MGAT5B Rabbit pAb
MGAT5B Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q3V5L5 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Dog, Human, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 89535 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MGAT5B |
| Epitope Specificity | 101-200/792 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Golgi apparatus membrane. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008] |
| Gene ID | 146664 |
|---|---|
| Other Names | Alpha-1, 6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B, 2.4.1.-, 2.4.1.155, Alpha-mannoside beta-1, 6-N-acetylglucosaminyltransferase B, GlcNAc-T Vb, GNT-Vb, hGnTVb, Mannoside acetylglucosaminyltransferase 5B, N-acetylglucosaminyl-transferase Vb, N-acetylglucosaminyltransferase IX, GNT-IX, MGAT5B, KIAA2008 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MGAT5B |
|---|---|
| Synonyms | KIAA2008 |
| Function | Glycosyltransferase that acts on alpha-linked mannose of N- glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6- linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway. |
| Cellular Location | Golgi apparatus membrane {ECO:0000250|UniProtKB:Q765H6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q765H6} |
| Tissue Location | Predominantly expressed in brain. Expressed in all areas of the adult and fetal brain. Also expressed at much lower levels in testis, spleen and thymus. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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