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NAALADL1 Rabbit pAb
NAALADL1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UQQ1 |
| Predicted | Human, Mouse, Rat, Dog, Pig, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 80558 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NAALADL1 |
| Epitope Specificity | 501-600/740 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Apical cell membrane; Single-pass type II membrane protein. Note: Ileal brush border membrane. |
| SIMILARITY | Belongs to the peptidase M28 family. M28B subfamily. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | NAALADL1 is a 740 amino acid single-pass type II membrane protein that localizes to the apical cell membrane. Belonging to the peptidase M28 family and the M28B subfamily, NAALADL1 is mainly expressed in the distal small intestine but is also expressed in spleen and tesits. NAALADL1 is considered a novel ileal brush border membrane protein,NAALADL1 is thought to have dipeptidyl-peptidase IV type activity. NAALADL1 exists as eight alternatively spliced isoforms and is encoded by a gene located on human chromosome 11q13.1. |
| Gene ID | 10004 |
|---|---|
| Other Names | Aminopeptidase NAALADL1, 3.4.11.-, 100 kDa ileum brush border membrane protein, I100, Ileal dipeptidylpeptidase, N-acetylated-alpha-linked acidic dipeptidase-like protein, NAALADase L, NAALADL1, NAALADASEL, NAALADL {ECO:0000303|PubMed:10085079} |
| Target/Specificity | Mainly expressed in the distal small intestine. Also expressed in the spleen and testis. Weak expression in the brain, locating mainly to the brain stem, amygdala, thalamus and ventral striatum. Isoform 2 and 3 isoform 3 are found in the small intestine and colon. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | NAALADL1 |
|---|---|
| Synonyms | NAALADASEL, NAALADL {ECO:0000303|PubMed: |
| Function | Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position (PubMed:25752612). Lacks carboxypeptidase activity. Lacks dipeptidyl- peptidase IV type activity (PubMed:25752612). |
| Cellular Location | Apical cell membrane {ECO:0000250|UniProtKB:O54697}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O54697}. Note=Ileal brush border membrane {ECO:0000250|UniProtKB:O54697} |
| Tissue Location | Detected in small intestine (at protein level) (PubMed:25752612). Detected in ileum (PubMed:9388249). Detected in small intestine, spleen and testis. Isoform 2 and isoform 3 are found in the small intestine and colon (PubMed:10085079) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
NAALADL1 is a 740 amino acid single-pass type II membrane protein that localizes to the apical cell membrane. Belonging to the peptidase M28 family and the M28B subfamily, NAALADL1 is mainly expressed in the distal small intestine but is also expressed in spleen and tesits. NAALADL1 is considered a novel ileal brush border membrane protein,NAALADL1 is thought to have dipeptidyl-peptidase IV type activity. NAALADL1 exists as eight alternatively spliced isoforms and is encoded by a gene located on human chromosome 11q13.1.
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