癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NALP5 Rabbit pAb
NALP5 Rabbit pAb
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- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | P59047 |
| Reactivity | Rat |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 134342 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NALP5 |
| Epitope Specificity | 101-200/1200 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Mitochondrion. Nucleus > nucleolus. Cytoplasm. In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008] |
| Other Names | NACHT, LRR and PYD domains-containing protein 5, Mater protein homolog, Maternal Antigen that Embryos Require, NLRP5, MATER {ECO:0000303|PubMed:19542546}, NALP5 |
|---|---|
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NLRP5 |
|---|---|
| Synonyms | MATER {ECO:0000303|PubMed:19542546}, NAL |
| Function | Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation. |
| Cellular Location | Cytoplasm. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Mitochondrion. Nucleus, nucleolus. Golgi apparatus. Note=Core component of cytoplasmic lattices in oocytes (PubMed:37922900). In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages (By similarity). From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). Expression largely disappears in blastocysts (By similarity). Located in mitochondria and nucleoli in primary follicle oocytes (By similarity) {ECO:0000250|UniProtKB:Q9R1M5, ECO:0000269|PubMed:37922900} |
| Tissue Location | Expressed in cumulus cells (at protein level) (PubMed:19542546). Highly abundant in oocytes and early embryos, however poorly expressed in somatic tissues such as the liver and spinal cord (PubMed:11925379, PubMed:30877238) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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