癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NOC4L Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q9BVI4 |
| Reactivity | Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 58468 Da |
| Gene ID | 79050 |
|---|---|
| Other Names | Nucleolar complex protein 4 homolog, NOC4 protein homolog, NOC4-like protein, Nucleolar complex-associated protein 4-like protein, NOC4L |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NOC4L |
|---|---|
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit (PubMed:34516797). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Required for the translation of mRNAs related to activation of regulatory and conventional T cells but is not essential for global translation in regulatory T cells (By similarity). Ensures correct nucleolar localization of small ribosomal subunit processome member EMG1 as part of a complex with NOP14 and UTP14A (PubMed:27798105). Blocks TLR4 endocytosis, causing inhibition of the TICAM1/TRIF signaling pathway (By similarity). This leads to reduced production of inflammatory cytokines which ameliorates local and systemic inflammation and influences insulin sensitivity (By similarity). Inhibits SIRT1-mediated deacetylation of TP53/p53 (PubMed:36030331). Required during early embryogenesis to ensure blastocyst formation (By similarity). |
| Cellular Location | Nucleus membrane; Multi-pass membrane protein. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Cytoplasmic granule. Early endosome {ECO:0000250|UniProtKB:Q8BHY2}. Note=Localizes to the nucleolus under normal conditions but translocates to the nucleoplasm and cytoplasm under stress conditions. |
| Tissue Location | In white adipose tissue (WAT), expressed predominantly in macrophages (PubMed:34675215). Expression in WAT is decreased in obese individuals (PubMed:34675215) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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