癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
QSOX2 Rabbit pAb
QSOX2 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q6ZRP7 |
| Reactivity | Mouse |
| Predicted | Rat, Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 77529 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human QSOX2 |
| Epitope Specificity | 101-200/698 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane. Secreted. Cell membrane. Nucleus membrane. Seems to be predominantly targeted to the nuclear and outer plasma membrane. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM, Jun 2009] |
| Gene ID | 169714 |
|---|---|
| Other Names | Sulfhydryl oxidase 2, 1.8.3.2, Neuroblastoma-derived sulfhydryl oxidase, Quiescin Q6-like protein 1, QSOX2, QSCN6L1, SOXN |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | QSOX2 (HGNC:30249) |
|---|---|
| Synonyms | QSCN6L1, SOXN |
| Function | Sulfhydryl oxidase that catalyzes the oxidation of protein thiol groups to form disulfide bonds, with the reduction of oxygen to hydrogen peroxide (By similarity). May contribute to disulfide bond formation in secreted proteins (By similarity). May play a role in regulating the sensitization of neuroblastoma cells for interferon- gamma-induced apoptosis (PubMed:14633699). Required for normal ovarian function (By similarity). |
| Cellular Location | Membrane; Single- pass membrane protein. Secreted. Cell membrane; Single-pass membrane protein. Nucleus membrane; Single- pass membrane protein. Note=Seems to be predominantly targeted to the nuclear and outer plasma membrane |
| Tissue Location | Expressed in pancreas, brain, placenta, kidney, heart and fetal tissues. Weakly expressed in lung, liver and skeletal muscles. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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