癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AFTPH Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, FC, WB, E |
|---|---|
| Primary Accession | Q6ULP2 |
| Other Accession | Q80WT5, NP_001002243.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 102113 Da |
| Antigen Region | 844-871 aa |
| Gene ID | 54812 |
|---|---|
| Other Names | Aftiphilin, AFTPH, AFTH |
| Target/Specificity | This AFTPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 844-871 amino acids from the C-terminal region of human AFTPH. |
| Dilution | IHC-P~~1:100~500 FC~~1:10~50 WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AFTPH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AFTPH |
|---|---|
| Synonyms | AFTH |
| Function | Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). |
| Cellular Location | Cytoplasm. Cytoplasm, perinuclear region. Cytoplasmic vesicle, clathrin-coated vesicle. Note=Co-localizes with AP1G1/AP- 1 in the cytoplasm (PubMed:14665628, PubMed:15758025). Recruited to the perinuclear region by AP1G1/AP-1 (PubMed:15758025) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
AFTPH may play a role in membrane trafficking.
REFERENCES
Lui-Roberts, W.W., et al. Mol. Biol. Cell 19(12):5072-5081(2008)
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
Hirst, J., et al. Mol. Biol. Cell 16(5):2554-2565(2005)
Burman, J.L., et al. FEBS Lett. 579(10):2177-2184(2005)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Mattera, R., et al. J. Biol. Chem. 279(9):8018-8028(2004)
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