癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ARIP4/RAD54L2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q9Y4B4 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 162769 Da |
| Gene ID | 23132 |
|---|---|
| Other Names | Helicase ARIP4, 3.6.4.12, Androgen receptor-interacting protein 4, RAD54-like protein 2, RAD54L2, ARIP4, KIAA0809 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RAD54L2 |
|---|---|
| Synonyms | ARIP4, KIAA0809 |
| Function | Helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner (By similarity). May stimulate the release of RNA polymerase II, that has paused near the transcription start sites of AR-targeted genes and unwind R-loops formed at these sites; R-loops result from the hybridization of the short RNA strand nascently synthesized by the paused RNA polymerase II molecule and the DNA template (PubMed:39028815). May also stimulate double-strand break formation by TOP2B, which appears important for transcriptional output (PubMed:39028815). Not able to remodel mononucleosomes in vitro (By similarity). |
| Cellular Location | Nucleus. Chromosome. Note=Localizes in speckle-like nuclear compartments (By similarity). Localizes to promoter proximal regions on chromatin (PubMed:39028815). {ECO:0000250|UniProtKB:Q99NG0, ECO:0000269|PubMed:39028815} |
| Tissue Location | Levels elevated in prostatic adenocarcinoma (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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