癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PNR/TAAR5 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q5QD14 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38220 Da |
| Gene ID | 215854 |
|---|---|
| Other Names | Trace amine-associated receptor 5, TaR-5, Trace amine receptor 5, mTaar5, Trimethylamine receptor, Taar5, Gm227 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Taar5 {ECO:0000303|PubMed:15718104, ECO:0000312|MGI:MGI:2685073} |
|---|---|
| Function | Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior (PubMed:16878137, PubMed:22545963, PubMed:23177478, PubMed:27208093, PubMed:30038239, PubMed:37225986, PubMed:37847527). Also activated by N-methylpiperidine (PubMed:22545963). Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant (PubMed:16878137, PubMed:23177478, PubMed:37225986). Trimethylamine-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (PubMed:37225986). Also required to provide olfactory input into limbic brain areas to regulate emotional behaviors likely via modulation of the serotonin system (PubMed:32194374, PubMed:33132188, PubMed:36038766). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:O14804}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14804} |
| Tissue Location | Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region (PubMed:16878137, PubMed:22837392). Present in the dorsal area of the main olfactory epithelium (PubMed:16878137, PubMed:22837392). Also present in the limbic brain areas receiving projection from the olfactory system and involved in the regulation of emotions (PubMed:33132188, PubMed:36038766). Also expressed in some brain regions outside the olfactory epithelium, such as the hippocampus, cerebellum, cortex, raphe nuclei, hypothalamus, and habenula (PubMed:32194374, PubMed:33132188, PubMed:34845253) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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