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Plexin A1 Rabbit pAb
Plexin A1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9UIW2 |
| Reactivity | Rat |
| Predicted | Pig, Human, Mouse, Rabbit, Dog, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 211067 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Plexin A1 |
| Epitope Specificity | 901-1000/1896 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane (Probable); Single-pass type I membrane protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury. |
| Gene ID | 5361 |
|---|---|
| Other Names | Plexin-A1, Semaphorin receptor NOV, PLXNA1 (HGNC:9099), NOV, PLXN1 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PLXNA1 (HGNC:9099) |
|---|---|
| Synonyms | NOV, PLXN1 |
| Function | Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis. |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P70206}; Single-pass type I membrane protein |
| Tissue Location | Detected in fetal brain, lung, liver and kidney. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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¥ 1,250.00
Cat# AP58050
