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KIF17 Rabbit pAb
KIF17 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q9P2E2 |
| Reactivity | Human |
| Predicted | Rat, Pig, Dog, Mouse, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 115068 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KIF17 |
| Epitope Specificity | 201-300/1029 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton (Probable). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The kinesin superfamily of proteins (KIFs) consists of a class of microtubule-dependent motors that play a major role in many cellular and developmental functions, including organelle transport, mitosis, meiosis, and possibly long-range signaling in neurons. The kinesin proteins are involved in organelle transport and are primarily associated with anterograde transport of vesicles and organelles in neurons, epithelial cells, and melanosomes with bidirectional transport of mitochondria. They also mediate transport between the endoplasmic reticulum (ER) and the Golgi complex. In neurons, kinesin motors conduct vesicular transport, such as of synaptic vesicle components to axons and of neurotransmitter receptors to dendrites. KIF17 belongs to the functionally diverse subgroup of the kinesin superfamily characterized by a N-terminal motor domain (N-IV class), that includes the KIF3 motor protein. KIF17 is specifically expressed in the brain, present in abundance in the gray matter, particularly in the hippocampus and cerebral cortex, but not in the white matter such as the optic nerve. |
| Gene ID | 57576 |
|---|---|
| Other Names | Kinesin-like protein KIF17, KIF3-related motor protein, KIF17, KIAA1405, KIF3X |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KIF17 |
|---|---|
| Synonyms | KIAA1405, KIF3X |
| Function | Together with RAB23 and IFT57, it is required for the localization of specific G protein-coupled receptors, such as dopamime receptor DRD1, to primary cilia (PubMed:26182404). In association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, cilium {ECO:0000250|UniProtKB:Q99PW8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99PW8}. Note=Localizes to dendrites of pyramidal neurons (By similarity). Does not localize to the axons or nuclei in cerebral cortex, hippocampus or olfactory bulb (By similarity). Co-localizes with NR2B-containing vesicles along microtubules (By similarity). {ECO:0000250|UniProtKB:Q99PW8} |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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