癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FLASH Rabbit pAb
FLASH Rabbit pAb
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- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9UKL3 |
| Reactivity | Mouse |
| Predicted | Rat, Pig, Dog, Human, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 222658 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FLASH/CASP8AP2 |
| Epitope Specificity | 1861-1982/1982 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. Nucleus. Note=Localizes to discrete nuclear foci. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8. There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity. Studies of FLASH protein suggested that this protein may be a component of the death inducing signaling complex that includes Fas receptor, Fas binding adapter FADD, and caspase 8, and plays a regulatory role in Fas mediated apoptosis. |
| Gene ID | 9994 |
|---|---|
| Other Names | CASP8-associated protein 2, FLICE-associated huge protein, CASP8AP2 (HGNC:1510) |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CASP8AP2 (HGNC:1510) |
|---|---|
| Function | Participates in TNF-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B (PubMed:12477726, PubMed:15698540). Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (PubMed:12477726, PubMed:15698540). Involved in TNF-induced activation of NF-kappa-B via a TRAF2-dependent pathway (By similarity). Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B (PubMed:17245429). Required for the activation of CASP8 in FAS-mediated apoptosis (PubMed:17245429). Involved for histone gene transcription and progression through S phase: required for the generation of mature histone mRNAs following the 3' end cleavage of histone pre-mRNAs (PubMed:17003125, PubMed:19854135, PubMed:32367068). |
| Cellular Location | Cytoplasm. Nucleus. Nucleus, PML body. Mitochondrion. Note=Exported from the nucleus to the mitochondria upon FAS activation |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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Cat# AP58085
