Quiescin Q6 Polyclonal Antibody

Purified Rabbit Polyclonal Antibody (Pab)

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P, IHC-F, IF, E
Primary Accession	O00391
Reactivity	Rat, Dog, Bovine
Host	Rabbit
Clonality	Polyclonal
Calculated MW	82578 Da

Additional Information
Gene ID	5768
Other Names	Sulfhydryl oxidase 1, hQSOX, 1.8.3.2, Quiescin Q6, QSOX1, QSCN6 {ECO:0000303\|PubMed:9878249}
Dilution	IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
Format	0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

Protein Information
Name	QSOX1
Synonyms	QSCN6 {ECO:0000303\|PubMed:9878249}
Function	Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:23867277, PubMed:30367560). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:22801504, PubMed:23867277, PubMed:30367560). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:23867277, PubMed:30367560).
Cellular Location	[Isoform 1]: Golgi apparatus membrane; Single-pass membrane protein. Secreted. Note=A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor
Tissue Location	Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney {ECO:0000269\|PubMed:10708601, ECO:0000269\|Ref.8}