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Unc18-3 Rabbit pAb
Unc18-3 Rabbit pAb
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Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | O00186 |
| Reactivity | Rat, Pig, Mouse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67764 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Unc18-3 |
| Epitope Specificity | 165-260/592 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm, cytosol. Cell membrane. |
| SIMILARITY | Belongs to the STXBP/unc-18/SEC1 family. |
| SUBUNIT | Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion (By similarity). Interacts with STX4. |
| Post-translational modifications | Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. |
| Gene ID | 6814 |
|---|---|
| Other Names | Syntaxin-binding protein 3, Platelet Sec1 protein, PSP, Protein unc-18 homolog 3, Unc18-3, Protein unc-18 homolog C, Unc-18C, STXBP3 |
| Target/Specificity | Megakaryocytes and platelets. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | STXBP3 |
|---|---|
| Function | Together with STX4 and VAMP2, may play a role in insulin- dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes. |
| Cellular Location | Cytoplasm, cytosol. Cell membrane. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated |
| Tissue Location | Megakaryocytes and platelets. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
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