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MRGX1 Rabbit pAb
MRGX1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q96LB2 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36250 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MRGX1 |
| Epitope Specificity | 21-120/322 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell Membrane; Multi-pass membrane protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the function of nociceptive neurons. This integral membrane protein may also regulate nociceptor development and/or the sensation or modulation of pain. There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways. G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons. |
| Gene ID | 259249 |
|---|---|
| Other Names | Mas-related G-protein coupled receptor member X1, Sensory neuron-specific G-protein coupled receptor 3/4, MRGPRX1 {ECO:0000303|PubMed:11551509, ECO:0000312|HGNC:HGNC:17962} |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MRGPRX1 {ECO:0000303|PubMed:11551509, ECO:0000312|HGNC:HGNC:17962} |
|---|---|
| Function | G protein-coupled receptor specifically expressed in sensory neurons of dorsal root ganglion, and which is involved in itch perception and pain transmission (PubMed:11850634, PubMed:20004959, PubMed:26582731, PubMed:33358893, PubMed:36302898, PubMed:37347749, PubMed:37591889, PubMed:39725036). Specifically activated by a variety of enkephalin (PENK) neuropeptides, such as BAM22 and BAM8-22, which induce itch in a histamine-independent manner (PubMed:11850634, PubMed:36302898, PubMed:37591889, PubMed:39725036). Activated by some tick defensins, such as I.persulcatus Def1 and I.ricinus Def2, evoking itch (PubMed:33358893). Also activated by conotoxin CNF-Tx2, inducing itch sensation (PubMed:30243794, PubMed:37591889). Activated by the antimalarial drug chloroquine; however, activation requires concentrations that exceed the chloroquine concentrations observed in plasma of patients undergoing chloroquine treatment (PubMed:20004959). Also activated following cleavage by the dust mite cysteine protease Der p1 (PubMed:28768771). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:36302898, PubMed:37591889). MRGPRX1 is both coupled to G(q) and G(i) G proteins: G(q) coupling activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers, leading to sensitize TRPV1 in pruriceptors, while G(i) coupling mediates inhibition of adenylate cyclase activity (PubMed:23074220, PubMed:36302898, PubMed:37347749, PubMed:37591889). Activation of MRGPRX1 in the peripheral nervous system elicits itch, evoking scratching (PubMed:28223516). MRGPRX1 activation in sensory neurons of the nasal mucosa mediates sneezing responses to irritants or influenza-virus (By similarity). Activation in the central nervous system dampens chronic pain: BAM8-22-binding at the central terminals prevents pain signals passing to spinal cord neurons, attenuating spinal nociceptive transmission (PubMed:28223516). Activation by CXCL17 induces chemotactic movement (PubMed:41167449). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Specifically expressed in small-diameter sensory neurons of dorsal root ganglion and trigeminal sensory neurons |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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