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NLRP9 Rabbit pAb
NLRP9 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q7RTR0 |
| Reactivity | Mouse |
| Predicted | Rat, Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 113312 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NLRP9 |
| Epitope Specificity | 701-800/991 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]. |
| Gene ID | 338321 |
|---|---|
| Other Names | NACHT, LRR and PYD domains-containing protein 9, Nucleotide-binding oligomerization domain protein 6, PYRIN and NACHT-containing protein 12, NLRP9, NALP9, NOD6, PAN12 |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NLRP9 |
|---|---|
| Synonyms | NALP9, NOD6, PAN12 |
| Function | As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q66X22}. Inflammasome |
| Tissue Location | Expressed in ileum intestinal epithelial cells. Not detected in peripheral blood mononuclear cells (PubMed:28636595) Expressed in cerebral endothelial cells and, at much lower levels, in brain pericytes (PubMed:28432035). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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