VKORC1 Antibody (N-term) 精选

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Anti-VKORC1 Antibody (N-term) at 1:1000 dilution + Human lung whole tissue lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution. Predicted band size : 18 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
VKORC1 Antibody (N-term) (Cat. #AP5859a) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the VKORC1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, E
Primary Accession	Q9BQB6
Other Accession	Q6B4J2, NP_076869.1
Reactivity	Human
Predicted	Bovine, Canine, Rabbit
Host	Rabbit
Clonality	Polyclonal
Isotype	Rabbit IgG
Calculated MW	18235 Da
Antigen Region	15-41 aa

Additional Information
Gene ID	79001
Other Names	Vitamin K epoxide reductase complex subunit 1, Vitamin K1 2, 3-epoxide reductase subunit 1, VKORC1, VKOR
Target/Specificity	This VKORC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-41 amino acids from the N-terminal region of human VKORC1.
Dilution	WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration.
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions	VKORC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Name	VKORC1 {ECO:0000303\|PubMed:14765194, ECO:0000312\|HGNC:HGNC:23663}
Function	Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.
Cellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location	Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas.

Research Areas

Application Protocols

Provided below are standard protocols that you may find useful for product applications.