癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NME6 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | O75414 |
| Reactivity | Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21142 Da |
| Gene ID | 10201 |
|---|---|
| Other Names | Nucleoside diphosphate kinase 6, NDK 6, NDP kinase 6, 2.7.4.6, Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha, nm23-H6, NME6 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NME6 {ECO:0000303|PubMed:10453732, ECO:0000312|HGNC:HGNC:20567} |
|---|---|
| Function | Catalytic subunit of a complex with RCC1L, which catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving the formation of a phosphohistidine intermediate (PubMed:10618642, PubMed:34789336, PubMed:37770567). Participates in the regulation of mitochondrial nucleotide levels, mitoribosome biogenesis, and mitochondrial RNA abundances (PubMed:10618642, PubMed:34789336, PubMed:37770567). Supplies pyrimidine ribonucleoside triphosphates (rNTPs) for mitochondrial transcription and is required for the maintenance of mitochondrial DNA (mtDNA) when the import of pyrimidine deoxyribonucleoside triphosphates (dNTPs) is limited from the cytosol is limited (PubMed:37439264). As a monomer, lacks nucleoside diphosphate kinase (NDPK) activity (PubMed:34789336). |
| Cellular Location | Mitochondrion matrix Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion. Note=Predominantly localized in mitochondrion matrix, however partially bound to mitochondrion inner membrane (MIM), peripherally bound and facing the matrix space |
| Tissue Location | Highly expressed in the heart, placenta, skeletal muscles, kidney, prostate, ovary, intestine, and spleen (PubMed:10453732, PubMed:10618642). Also expressed in various cell lines and the expression levels differed among cell lines (PubMed:10618642). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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