癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TMUB1 Rabbit pAb
TMUB1 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9BVT8 |
| Predicted | Rat, Pig, Dog, Human, Mouse, Rabbit, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 26261 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TMUB1 |
| Epitope Specificity | 101-200/246 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Nucleus. Note=Predominantly nuclear during growth arrest (By similarity). Actively exported from the nucleus in dividing cells. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation. |
| Gene ID | 83590 |
|---|---|
| Other Names | Transmembrane and ubiquitin-like domain-containing protein 1, Dendritic cell-derived ubiquitin-like protein, DULP, Hepatocyte odd protein shuttling protein, Ubiquitin-like protein SB144, iHOPS, TMUB1, C7orf21, DULP, HOPS |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TMUB1 |
|---|---|
| Synonyms | C7orf21, DULP, HOPS |
| Function | Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9JMG3}; Multi- pass membrane protein {ECO:0000250|UniProtKB:Q9JMG3}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9JMG3}. Recycling endosome {ECO:0000250|UniProtKB:Q53AQ4}. Cytoplasm {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3} Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3} |
| Tissue Location | Ubiquitously expressed with highest levels in mammary and thyroid glands, bone marrow and spleen; limited expression in cardiac, pancreatic and ovarian tissues |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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