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Beta tubulin cofactor D Rabbit pAb
Beta tubulin cofactor D Rabbit pAb
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Application 
| WB |
|---|---|
| Primary Accession | Q9BTW9.2 |
| Reactivity | Rat, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 133 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TBCD/Beta tubulin cofactor D |
| Epitope Specificity | 401-500/1192 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell junction, tight junction (Bysimilarity). Lateral cell membrane (By similarity). Cytoplasm (Bysimilarity). Cell junction, adherens junction (By similarity).Note=Localized in cell-cell contacts (By similarity). |
| SIMILARITY | Belongs to the TBCD family.Contains 3 HEAT repeats. |
| SUBUNIT | Found in a complex with at least ARL2, PPP2CB, PPP2R1A,PPP2R2A, PPP2R5E and TBCD. Interacts with PPP2CB. Interacts withARL2 (By similarity). Supercomplex made of cofactors A to E.Cofactors A and D function by capturing and stabilizing tubulin ina quasi-native conformation. Cofactor E binds to the cofactorD-tubulin complex; interaction with cofactor C then causes therelease of tubulin polypeptides that are committed to the nativestate. Interacts with ARL2; interaction is enhanced with theGDP-bound form of ARL2. Does not interact with ARL3, ARL4A andARL4D. Interacts with beta tubulin. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. |
| Other Names | Tubulin-specific chaperone D, Beta-tubulin cofactor D, tfcD, SSD-1, Tubulin-folding cofactor D, TBCD, KIAA0988, SSD1, TFCD |
|---|---|
| Target/Specificity | Ubiquitously expressed. |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase-activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.
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