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AMIGO3 Rabbit pAb
AMIGO3 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
| Primary Accession | Q86WK7 |
|---|---|
| Predicted | Pig, Human, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 55250 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human AMIGO3 |
| Epitope Specificity | 233-300/504 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Single-pass type I membrane protein |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO1, AMIGO2 and AMIGO3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO1 and AMIGO2, AMIGO3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction. |
| Gene ID | 386724 |
|---|---|
| Other Names | Amphoterin-induced protein 3, AMIGO-3, Alivin-3, AMIGO3 {ECO:0000312|EMBL:AAO48944.1} |
| Dilution | ICC/IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | AMIGO3 {ECO:0000312|EMBL:AAO48944.1} |
|---|---|
| Function | May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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